What is Mazdutide?
Mazdutide is a synthetic analogue of oxyntomodulin, a naturally occurring gut hormone that binds both the GLP-1 and glucagon receptors. Where most incretin research compounds are engineered from GLP-1 itself, Mazdutide starts from a molecule that is already dual-acting and modifies it for stability and a longer half-life.
- Class: dual GLP-1 / glucagon receptor agonist
- Scientific name: Mazdutide (LY3305677 / IBI362)
- Scaffold: oxyntomodulin analogue
- Supply: 10mg lyophilised vial, ≥98% purity
The research context
In laboratory settings Mazdutide is studied for its simultaneous engagement of the GLP-1 and glucagon receptors. Research interest commonly focuses on energy-expenditure signalling, appetite-pathway modelling and comparative receptor-affinity work against single and triple agonists under controlled experimental conditions.
Published literature on this compound is clinical research data summarised for context only. It is not medical advice, and the material supplied here is not for human use.
Mazdutide vs Retatrutide vs Tirzepatide vs Semaglutide
| Peptide | Receptors | Notes |
|---|---|---|
| Mazdutide | GLP-1 + glucagon | Oxyntomodulin scaffold; pairs intake with expenditure signalling. |
| Tirzepatide | GLP-1 + GIP | Dual incretin agonist; largest dataset of the dual agonists. |
| Retatrutide | GLP-1 + GIP + glucagon | Triple agonist — adds GIP on top of Mazdutide’s pairing. |
| Semaglutide | GLP-1 only | Single agonist; the reference compound for the class. |
See also the Retatrutide UK guide, Tirzepatide UK guide and GLP-1 research peptide range.
How to reconstitute Mazdutide 10mg
Mazdutide is water-soluble, so it needs bacteriostatic water only — no acetic acid water step.
- Wipe the stopper with an alcohol swab and allow it to dry.
- Draw your bacteriostatic water and add it slowly down the inside wall of the vial.
- Swirl gently until the powder is fully dissolved — never shake.
- Label with concentration and date, then refrigerate at 2–8°C.
For any target concentration, use the free peptide reconstitution calculator.
Mazdutide price UK — what you actually pay
Mazdutide for sale in the UK is usually quoted per vial, but the quoted price is rarely the whole cost. Minimum spends, paid supplies and COAs on request all add to it.
| What you get | Peptides UK 4U |
|---|---|
| Mazdutide 10mg vial | £62.00 |
| Cost per mg | £6.20 / mg |
| Typical UK market price | £65–£80 per 10mg |
| Minimum order value | None — buy a single vial |
| 4 needles + 4 alcohol swabs | Free — opt in at checkout |
| Batch COA | Published, no request needed |
| UK dispatch | Same day before 2pm, Mon–Fri |
Purity, testing & UK delivery
- Independently HPLC tested, ≥98% purity, batch number matched to the vial.
- Batch Certificates of Analysis published openly.
- UK-held stock once the batch lands — same working day dispatch before 2pm, Mon–Fri.
- Royal Mail Tracked 24 with photo confirmation, discreet plain packaging.
- Free 4 needles + 4 alcohol swabs with every vial — opt in at checkout.
Related guides
Frequently asked questions
What is Mazdutide?
Mazdutide (LY3305677, also referenced as IBI362) is a synthetic analogue of oxyntomodulin that activates both the GLP-1 receptor and the glucagon receptor. That dual-pathway profile is what separates it from single-agonist analogues such as semaglutide.
Where can I buy Mazdutide in the UK?
Peptides UK 4U supplies Mazdutide 10mg at £62 per vial with no minimum order. The first UK batch is landing shortly — reserve your place on the waiting list and we will notify you the day it arrives.
How much is Mazdutide 10mg in the UK?
Ours is £62 per 10mg vial, which works out at £6.20 per mg. UK suppliers typically list Mazdutide 10mg between £55 and £90, with most sitting around £65–£80, so this sits at the value end of the market with free needles and swabs at checkout.
Is Mazdutide the same as Retatrutide?
No. Mazdutide is a dual GLP-1/glucagon agonist built on the oxyntomodulin scaffold. Retatrutide is a triple agonist that adds GIP receptor activity on top of those two pathways.
How does Mazdutide differ from Tirzepatide?
Both are dual agonists, but the receptor pairing differs. Tirzepatide combines GLP-1 with GIP; Mazdutide combines GLP-1 with glucagon, pairing an intake pathway with an energy-expenditure pathway.
What purity is your Mazdutide?
Every 10mg vial is tested to at least 98% purity by RP-HPLC. A batch-specific Certificate of Analysis is published as soon as the batch lands, and the batch number on the vial matches the published COA.
How is Mazdutide reconstituted?
Mazdutide is water-soluble, so bacteriostatic water alone is enough — no acetic acid water needed. Add the water slowly down the side of the vial and swirl gently until clear; never shake. Use the free peptide calculator to work out your target concentration.
How should Mazdutide be stored?
Store the unopened lyophilised vial cool and dry, or at -20°C for extended stability. Once reconstituted, refrigerate at 2–8°C, protect from light and avoid repeated freeze-thaw cycles.
Is Mazdutide legal in the UK?
Mazdutide is legal to buy and possess in the UK for laboratory research purposes. It is not a licensed medicine in the UK, is not prescribed on the NHS, and is supplied strictly for in vitro research use only — not for human or animal consumption.
When will Mazdutide be in stock?
Stock is expected within the next two to three weeks. Join the newsletter or message us on WhatsApp and we will let you know the moment the batch lands.
Is there a minimum order for Mazdutide?
No. There is no minimum order value at Peptides UK 4U — a single Mazdutide 10mg vial can be ordered on its own, unlike suppliers that require £100–£150 before you can check out.
Do you supply a Mazdutide pen?
Mazdutide is supplied as a 10mg lyophilised vial. Our pre-filled Quick Pen and cartridge preparations are offered as format options on suitable products — see the peptide pens page for the current list.
Disclaimer: All products sold by Peptides UK 4U are for laboratory and research purposes only. They are not intended for human or animal consumption, diagnosis, treatment or prevention of any disease.