What is CagriSema?
CagriSema is shorthand for the combination of cagrilintide and semaglutide. The interest in the pairing comes from the fact that the two peptides hit entirely separate receptor systems: semaglutide binds the GLP-1 receptor, while cagrilintide is a long-acting amylin analogue acting across the amylin receptor family (AMY1R, AMY2R, AMY3R) with calcitonin-receptor cross-reactivity.
In laboratory work that separation matters — it allows dual-pathway signalling to be characterised without the confound of two compounds competing for the same receptor.
Cagrilintide vs semaglutide
| Property | Cagrilintide | Semaglutide |
|---|---|---|
| Class | Long-acting amylin analogue | GLP-1 receptor analogue |
| Receptors | AMY1R / AMY2R / AMY3R | GLP-1R |
| Reported half-life | ~7 days | ~7 days |
| Vials stocked | 5mg, 10mg | 10mg, 20mg, 30mg |
| Price from | £59.99 (10mg) | £49.99 (10mg) |
Purity, testing & UK delivery
- Independently HPLC and mass-spec tested, 99%+ purity.
- Batch Certificates of Analysis published openly.
- UK-held stock — Same-day Royal Mail Tracked 24 dispatch (order by 1pm, Mon-Fri).
- Royal Mail tracked, discreet plain packaging.
Frequently asked questions
What is CagriSema?
CagriSema is the research shorthand for cagrilintide combined with semaglutide — a long-acting amylin analogue paired with a GLP-1 receptor analogue. The two peptides act on completely separate receptor families, which is why they are studied together in dual-pathway metabolic models.
How much does CagriSema cost in the UK?
Buying both halves separately: Cagrilintide 10mg is £56.99 and Semaglutide 10mg is £49.99 (30mg is £99.99). Both are UK-held stock with same-day Royal Mail Tracked 24 dispatch (order by 1pm, Mon-Fri).
What is the difference between cagrilintide and semaglutide?
Semaglutide is a GLP-1 receptor analogue. Cagrilintide is a long-acting analogue of amylin acting on the AMY1R/AMY2R/AMY3R receptor family with calcitonin-receptor cross-reactivity. They are structurally and mechanistically distinct, which is the entire reason they are paired in research.
What are the reported half-lives?
Published pharmacokinetic literature reports roughly 7 days for cagrilintide and roughly 7 days for semaglutide.
Is CagriSema legal in the UK?
Cagrilintide and semaglutide are legal to buy and possess in the UK for laboratory research purposes. Neither is supplied as a licensed medicine — both are strictly for in vitro research use only, not for human or animal consumption.
How do I verify purity?
Our batches are tested to at least 98% purity by RP-HPLC with mass-spec confirmation, and the batch number on the vial matches a Certificate of Analysis published openly on our COA page.