What is CagriSema?
CagriSema is shorthand for the combination of cagrilintide and semaglutide. The interest in the pairing comes from the fact that the two peptides hit entirely separate receptor systems: semaglutide binds the GLP-1 receptor, while cagrilintide is a long-acting amylin analogue acting across the amylin receptor family (AMY1R, AMY2R, AMY3R) with calcitonin-receptor cross-reactivity.
In laboratory work that separation matters — it allows dual-pathway signalling to be characterised without the confound of two compounds competing for the same receptor.
Cagrilintide vs semaglutide
| Property | Cagrilintide | Semaglutide |
|---|---|---|
| Class | Long-acting amylin analogue | GLP-1 receptor analogue |
| Receptors | AMY1R / AMY2R / AMY3R | GLP-1R |
| Reported half-life | ~7 days | ~7 days |
| Vials stocked | 5mg, 10mg | 10mg, 20mg, 30mg |
| Price from | £59.99 (10mg) | £49.99 (10mg) |
Why we supply two vials, not one
- Each peptide gets its own HPLC and mass-spec Certificate of Analysis.
- Concentrations can be varied independently between arms of a study.
- Stability characterisation stays valid — pre-mixed blends invalidate it.
- Any purity question can be traced back to a single batch number.
Reconstitute each vial separately with bacteriostatic water, added slowly down the inside wall and swirled — never shaken. Use the free peptide reconstitution calculator for exact volumes.
Purity, testing & UK delivery
- Independently HPLC and mass-spec tested, ≥98% purity.
- Batch Certificates of Analysis published openly.
- UK-held stock — same working day dispatch before 2pm, Mon–Fri.
- Royal Mail Tracked 24, discreet plain packaging.
Frequently asked questions
What is CagriSema?
CagriSema is the research shorthand for cagrilintide combined with semaglutide — a long-acting amylin analogue paired with a GLP-1 receptor analogue. The two peptides act on completely separate receptor families, which is why they are studied together in dual-pathway metabolic models.
Do you sell CagriSema as a single vial?
No. We supply cagrilintide and semaglutide as separate lyophilised vials so each can be reconstituted, characterised and purity-verified independently. Mixing peptides in one vial compromises stability data and makes independent HPLC verification impossible.
How much does CagriSema cost in the UK?
Buying both halves separately: Cagrilintide 10mg is £59.99 and Semaglutide 10mg is £49.99 (30mg is £99.99). Both are UK-held stock with same-day dispatch on orders placed before 2pm.
What is the difference between cagrilintide and semaglutide?
Semaglutide is a GLP-1 receptor analogue. Cagrilintide is a long-acting analogue of amylin acting on the AMY1R/AMY2R/AMY3R receptor family with calcitonin-receptor cross-reactivity. They are structurally and mechanistically distinct, which is the entire reason they are paired in research.
What are the reported half-lives?
Published pharmacokinetic literature reports roughly 7 days for cagrilintide and roughly 7 days for semaglutide, which is why protocols in the literature use once-weekly administration for both.
How is each peptide reconstituted?
Reconstitute each vial separately with bacteriostatic water added slowly down the inside wall — swirl, never shake. Keep both peptides at matched concentrations if you want directly comparable in vitro results. Use the free peptide calculator for exact volumes.
Is CagriSema legal in the UK?
Cagrilintide and semaglutide are legal to buy and possess in the UK for laboratory research purposes. Neither is supplied as a licensed medicine — both are strictly for in vitro research use only, not for human or animal consumption.
How do I verify purity?
Every batch is tested to at least 98% purity by RP-HPLC with mass-spec confirmation, and the batch number on the vial matches a Certificate of Analysis published openly on our COA page.