Cagrilintide 5mg / 10mg

Cagrilintide is a long-acting synthetic analogue of the pancreatic hormone amylin, engineered with a fatty-acid side chain that extends its plasma half-life relative to native amylin. Supplied in a 10mg lyophilised vial, it is prepared to 99%+ purity by RP-HPLC for laboratory use only.

Classification: Long-acting synthetic analogue of the pancreatic hormone amylin (islet amyloid polypeptide, IAPP). Structurally modified with a C20 fatty-acid side chain to extend plasma half-life relative to native amylin.

Cagrilintide is studied in vitro for its affinity across the amylin receptor family (AMY1R, AMY2R, AMY3R) and its calcitonin-receptor cross-reactivity. Research groups frequently pair Cagrilintide with GLP-1 analogues such as Semaglutide to model complementary metabolic pathways under controlled conditions.

This summary describes published preclinical and, where applicable, clinical research. It is not a medical claim and does not describe or endorse any human use of the compound as sold by Peptides UK 4U.

Cagrilintide is investigated as an agonist across the amylin receptor family — AMY1R, AMY2R and AMY3R — which are heterodimers of the calcitonin receptor and receptor activity-modifying proteins (RAMPs). Preclinical research explores its role in central satiety signalling, gastric-emptying pathways and glucagon suppression, often studied alongside GLP-1 receptor agonists as a model of complementary metabolic signalling. All findings referenced here are from published preclinical and early clinical literature and are presented as ongoing research, not established clinical fact.

Reconstitute with bacteriostatic water in a sterile environment. Cagrilintide is typically paired with GLP-1 analogues in dual-agonist research studies — keep both peptides at matched concentrations for reproducible in vitro comparisons.

Storage & stability

• Lyophilised vials: store below -18°C, protected from light.
• Reconstituted solution: refrigerate at 2–8°C.
• Avoid repeated freeze-thaw cycles to preserve peptide integrity.

For in vitro research use only. We do not provide preparation, dosing or usage guidance.

Peptide Type

Long-acting amylin receptor analogue

Molecular formula

C₁₈₇H₂₈₅N₅₅O₅₉S₂

Molecular weight

≈4,289 Da

Form

Lyophilised powder

Quantity

10mg per vial

Purity

99%+ by RP-HPLC

Solubility

Water / bacteriostatic water

CAS

1415456-99-3

Certificate of Analysis: Available on request from our support team.

• Enebo LB et al., The Lancet 397(10286):1736–1748 (2021) — cagrilintide + semaglutide combination pharmacology
• Lau DCW et al., Nature Metabolism (2021) — amylin receptor pharmacology
• Hay DL et al., Pharmacological Reviews 67(3):564–600 (2015) — amylin receptor family and RAMPs

References are provided for educational context. Citation does not imply endorsement of any specific use.