Cagrilintide 10mg
Metabolic
Overview
Cagrilintide is a long-acting synthetic analogue of the pancreatic hormone amylin, engineered with a fatty-acid side chain that extends its plasma half-life relative to native amylin. Supplied in a 10mg lyophilised vial, it is prepared to ≥98% purity by RP-HPLC for laboratory use only.
Classification: Long-acting synthetic analogue of the pancreatic hormone amylin (islet amyloid polypeptide, IAPP). Structurally modified with a C20 fatty-acid side chain to extend plasma half-life relative to native amylin.
Research background
Cagrilintide is studied in vitro for its affinity across the amylin receptor family (AMY1R, AMY2R, AMY3R) and its calcitonin-receptor cross-reactivity. Research groups frequently pair Cagrilintide with GLP-1 analogues such as Semaglutide to model complementary metabolic pathways under controlled conditions.
This summary describes published preclinical and, where applicable, clinical research. It is not a medical claim and does not describe or endorse any human use of the compound as sold by Peptides UK 4U.
Mechanism of action (under investigation)
Cagrilintide is investigated as an agonist across the amylin receptor family — AMY1R, AMY2R and AMY3R — which are heterodimers of the calcitonin receptor and receptor activity-modifying proteins (RAMPs). Preclinical research explores its role in central satiety signalling, gastric-emptying pathways and glucagon suppression, often studied alongside GLP-1 receptor agonists as a model of complementary metabolic signalling. All findings referenced here are from published preclinical and early clinical literature and are presented as ongoing research, not established clinical fact.
Laboratory handling
Reconstitute with bacteriostatic water in a sterile environment. Cagrilintide is typically paired with GLP-1 analogues in dual-agonist research protocols — keep both peptides at matched concentrations for reproducible in vitro comparisons.
Storage & stability
- Lyophilised vials: store below -18°C, protected from light.
- Reconstituted solution: refrigerate at 2–8°C and use within 28 days.
- Avoid repeated freeze-thaw cycles to preserve peptide integrity.
For reconstitution volumes and target working concentrations use our peptide calculator. We do not publish dosing protocols for human use.
Product specifications
- Peptide Type
- Long-acting amylin receptor analogue
- Molecular formula
- C₁₈₇H₂₈₅N₅₅O₅₉S₂
- Molecular weight
- ≈4,289 Da
- Form
- Lyophilised powder
- Quantity
- 10mg per vial
- Purity
- ≥98% by RP-HPLC
- Solubility
- Water / bacteriostatic water
- CAS
- 1415456-99-3
Certificate of Analysis: Available on request from our support team.
Frequently asked questions
What is Cagrilintide used for in research?
Cagrilintide is used in vitro to study long-acting amylin-receptor signalling and, alongside GLP-1 analogues, as a reference compound in dual-pathway metabolic research.
What purity is your Cagrilintide?
Every batch is tested to ≥98% purity by RP-HPLC. A batch-specific Certificate of Analysis is available on the COA page and on request.
How is Cagrilintide reconstituted?
Reconstitute the lyophilised 10mg vial with bacteriostatic water in a sterile laboratory environment. For target concentrations and volumes, use our peptide calculator.
What is the reported half-life of Cagrilintide?
Published pharmacokinetic literature reports a half-life of approximately 7 days for cagrilintide, which is why research protocols typically use once-weekly administration.
Can Cagrilintide be mixed with other peptides in a single vial?
We don't recommend mixing peptides in a single vial — it compromises stability characterisation and makes independent purity verification impossible. Prepare and store each peptide separately.
How should reconstituted Cagrilintide be stored?
Store the reconstituted solution at 2–8°C and use within 28 days. Lyophilised vials are stable below -18°C for extended periods. Avoid repeated freeze-thaw cycles.
Do you ship Cagrilintide from the UK?
Yes — all Cagrilintide vials are stocked and dispatched from the UK with next-working-day delivery on orders placed before 2pm.
Is Cagrilintide the same as Semaglutide?
No. Semaglutide is a GLP-1 receptor analogue; Cagrilintide is a long-acting amylin analogue acting on a completely different receptor family (AMY1R/AMY2R/AMY3R). The two are structurally and mechanistically distinct.
References
- Enebo LB et al., The Lancet 397(10286):1736–1748 (2021) — cagrilintide + semaglutide combination pharmacology
- Lau DCW et al., Nature Metabolism (2021) — amylin receptor pharmacology
- Hay DL et al., Pharmacological Reviews 67(3):564–600 (2015) — amylin receptor family and RAMPs
References are provided for educational context. Citation does not imply endorsement of any specific use.
Disclaimer: This article is provided for laboratory and educational purposes only. It is not medical advice and does not describe or endorse any human use. All products sold by Peptides UK 4U are for laboratory research only, are not for human or veterinary consumption, and are not intended to diagnose, treat, cure or prevent any disease.