CJC-1295 UK — Mechanism, DAC vs No-DAC & Research Use
Also known as Modified GRF (1-29)
CJC-1295 is a synthetic analogue of growth hormone releasing hormone (GHRH). It is one of the most widely studied peptides in the growth hormone axis literature, usually discussed alongside Ipamorelin because the two act on different receptors within the same pathway.
This page explains the mechanism, the important difference between the DAC and no-DAC versions, and how CJC-1295 is handled in a research setting.
For in vitro research use only — not for human or animal consumption. Not a licensed medicine in the UK. Nothing on this page is medical advice.
What is CJC-1295?
CJC-1295 is a modified fragment of GHRH — the hypothalamic hormone that signals the pituitary to release growth hormone. Native GHRH is broken down within minutes; CJC-1295 substitutes several amino acids to resist enzymatic degradation, which is why it appears so frequently in half-life research.
The base molecule without the drug affinity complex is often labelled Modified GRF (1-29) or CJC-1295 no-DAC.
DAC vs no-DAC — the key distinction
The drug affinity complex (DAC) binds the peptide to serum albumin, extending its circulating half-life from minutes to days. That single modification changes the research profile completely.
- CJC-1295 no-DAC (Mod GRF 1-29) — short acting, produces a pulsatile signal closer to natural GHRH release.
- CJC-1295 with DAC — long acting, produces a sustained elevation rather than a pulse.
- Literature comparing the two focuses on whether pulsatile or continuous signalling is the more relevant model.
Why CJC-1295 and Ipamorelin appear together
CJC-1295 acts on the GHRH receptor; Ipamorelin acts on the ghrelin/GHS receptor. Because they engage separate receptors in the same axis, research protocols frequently study them in combination to observe additive signalling rather than either compound alone.
Handling and storage
Supplied lyophilised. Reconstitute with bacteriostatic water added slowly down the vial wall, swirl gently, then refrigerate at 2–8°C and use within 28 days. Protect from light and avoid repeated freeze-thaw cycles.
Buying this peptide in the UK
- UK-held stock — same working day dispatch on orders before 2pm, Mon–Fri.
- Royal Mail Tracked 24 with photo confirmation on every parcel.
- Independent HPLC and mass-spec testing with a batch-matched Certificate of Analysis.
- Discreet plain packaging and normal UK card checkout — no crypto required.
- Free 4 needles + 4 alcohol swabs with every vial — opt in at checkout.
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View full shopFrequently asked questions
What is the difference between CJC-1295 and Ipamorelin?
CJC-1295 is a GHRH analogue acting on the GHRH receptor. Ipamorelin is a growth hormone secretagogue acting on the ghrelin receptor. They are different receptors within the same growth hormone axis, which is why the literature often studies them together.
Is CJC-1295 legal in the UK?
CJC-1295 is legal to buy and possess in the UK for laboratory research purposes. It is not a licensed medicine in the UK, is not prescribed by the NHS, and is supplied strictly for in vitro research use only — not for human or animal consumption.
How is CJC-1295 reconstituted?
CJC-1295 is supplied lyophilised. Add bacteriostatic water slowly down the inside wall of the vial and swirl gently — never shake, as agitation can damage the peptide chain. Once dissolved, store at 2–8°C and use within 28 days. Use our free peptide calculator for exact volumes rather than following generic charts.
Do you supply a Certificate of Analysis for CJC-1295?
Yes. Every batch is independently HPLC and mass-spec tested and the batch number on the vial matches a published Certificate of Analysis, so purity can be verified before use.
How fast is UK delivery?
Stock is held in the UK. Orders placed before 2pm Monday–Friday are dispatched the same working day by Royal Mail Tracked 24 with photo confirmation, in discreet plain packaging with no product names on the outside.
Disclaimer: All products sold by Peptides UK 4U are for laboratory and research purposes only. They are not intended for human or animal consumption, diagnosis, treatment or prevention of any disease.