Semaglutide 30mg
Metabolic
Overview
Semaglutide is a long-acting 31-residue GLP-1 receptor analogue with a C18 fatty-diacid modification at Lys26 that extends its plasma half-life relative to native GLP-1. Supplied as a 30mg sterile lyophilised powder, verified to ≥98% purity by RP-HPLC and confirmed by mass spectrometry.
Classification: Semaglutide — a synthetic 31 amino-acid analogue of native GLP-1(7–37), with two amino-acid substitutions and a C18 fatty-diacid side chain (via a spacer) that enables albumin binding and extends plasma half-life.
Research background
Semaglutide is a reference GLP-1 agonist in in vitro receptor pharmacology — used to characterise cAMP response, β-arrestin recruitment, receptor internalisation and comparator responses when benchmarking dual (Tirzepatide) and triple (Retatrutide) agonists.
This summary describes published preclinical and, where applicable, clinical research. It is not a medical claim and does not describe or endorse any human use of the compound as sold by Peptides UK 4U.
Mechanism of action (under investigation)
Semaglutide is characterised in the published literature as a selective GLP-1 receptor agonist. It has served as the reference GLP-1 analogue in modern incretin research and is widely used as a benchmark compound in in vitro and preclinical studies of GLP-1 receptor signalling.
Laboratory handling
Reconstitute the 30mg vial with bacteriostatic water in a sterile environment. Semaglutide's fatty-acid modification supports good stability in refrigerated aqueous solution — prepare working aliquots to avoid repeated freeze-thaw cycles.
Storage & stability
- Lyophilised vials: store below -18°C, protected from light.
- Reconstituted solution: refrigerate at 2–8°C and use within 30 days.
- Avoid repeated freeze-thaw cycles to preserve peptide integrity.
For reconstitution volumes and target working concentrations use our peptide calculator. We do not publish dosing protocols for human use.
Product specifications
- Peptide Type
- Long-acting GLP-1 receptor analogue
- Sequence length
- 31 amino acids
- Molecular weight
- ≈4,113 Da
- Form
- Lyophilised powder
- Quantity
- 30mg per vial
- Purity
- ≥98% by RP-HPLC + MS
- Solubility
- Water / bacteriostatic water
- CAS
- 910463-68-2
Certificate of Analysis: Batch-specific COA available. View COAs.
Frequently asked questions
What is Semaglutide used for in research?
Semaglutide is a reference GLP-1 receptor analogue used in vitro to study receptor binding, cAMP signalling, β-arrestin recruitment and comparator pharmacology against dual and triple agonists such as Tirzepatide and Retatrutide.
What is the reported half-life of Semaglutide?
Published pharmacokinetic literature reports a half-life of approximately 7 days, enabled by the C18 fatty-diacid modification at Lys26 that binds albumin. This supports once-weekly administration in research protocols.
What purity is your Semaglutide?
Every 30mg vial is tested to ≥98% purity by RP-HPLC and confirmed by mass spectrometry (~4,113 Da). A batch-specific COA is published on our COA page.
How is the 30mg vial reconstituted?
Reconstitute with bacteriostatic water in a sterile laboratory environment. For target concentrations and volumes, use our peptide calculator.
How does Semaglutide compare with Tirzepatide?
Semaglutide activates the GLP-1 receptor only; Tirzepatide is a dual GLP-1 / GIP agonist. The second receptor is the main variable researchers compare when characterising incretin pharmacology.
How long is reconstituted Semaglutide stable?
Kept refrigerated at 2–8°C and protected from light, reconstituted Semaglutide remains suitable for in vitro research use for up to ~30 days. Avoid repeated freeze-thaw cycles.
Do you ship Semaglutide from the UK?
Yes — all Semaglutide vials are UK-stocked with next-working-day dispatch on orders placed before 2pm.
References
- Lau J et al., Journal of Medicinal Chemistry 58(18):7370–7380 (2015) — semaglutide discovery
- Marso SP et al., NEJM 375(19):1834–1844 (2016) — SUSTAIN-6
- Wilding JPH et al., NEJM 384(11):989–1002 (2021) — STEP 1
References are provided for educational context. Citation does not imply endorsement of any specific use.
Disclaimer: This article is provided for laboratory and educational purposes only. It is not medical advice and does not describe or endorse any human use. All products sold by Peptides UK 4U are for laboratory research only, are not for human or veterinary consumption, and are not intended to diagnose, treat, cure or prevent any disease.